Pathogen Research

Unlocking the mysteries of infectious diseases

Pathogen Research 2017-11-08T07:30:45+00:00
Pathogen Research

Codon Genomics is actively involved in the clinical pathogen research in hoping to create a healthier world with reduced infectious diseases. We offer and apply latest technology to assist in pathogen research and clinical microbiology projects, such as:

What we do

Assembly and annotation of pathogen genomes and transcriptomes using the latest cutting-edge technology provide a rich reservoir for discovery of essential genes, virulence factors and pathways conferring pathogenic capacity. The understanding of pathogenesis catalyses the identification of targets for development of novel antibacterial drugs and new vaccines.

Direct genetic analysis of genomes present in an environmental sample, without the needs for individual microbes isolation by subculturing which is limited by time, labour and high percentage of unculturable microbes.

For example, by using viral metagenomics, a Brazilian research group is able to accurately detect and diagnose the presence of Zika virus in the amniotic fluid samples of two pregnant women.

Simultaneous profiling of transcriptomes of host and pathogen during the infection stage, and uses in silico analysis to distinguish species-specific transcripts.

The comprehensive information on the cross talk between host and pathogen enables the elucidation of pathogenic pathways and infection mechanism of the pathogens, and assist in the future development of preventive strategies.

Our achievements

Kuan, C.S., Chan, C.L., Yew, S.M., Toh, Y.F., Khoo, J.S., Chong, J., Lee, K.W., Tan, Y.C., Yee, W.Y., Ngeow, Y.F. and Ng, K.P., 2015. Genome analysis of the first extensively drug-resistant (XDR) Mycobacterium tuberculosis in Malaysia provides insights into the genetic basis of its biology and drug resistance. PloS one10(6), p.e0131694.

Tan, K.K., Tan, Y.C., Chang, L.Y., Lee, K.W., Nore, S.S., Yee, W.Y., Isa, M.N.M., Jafar, F.L., Hoh, C.C. and AbuBakar, S., 2015. Full genome SNP-based phylogenetic analysis reveals the origin and global spread of Brucella melitensis. BMC genomics16(1), p.93.

Yew, S.M., Chan, C.L., Ngeow, Y.F., Toh, Y.F., Na, S.L., Lee, K.W., Hoh, C.C., Yee, W.Y., Ng, K.P. and Kuan, C.S., 2016. Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes. Scientific reports6.

Yew, S.M., Chan, C.L., Lee, K.W., Na, S.L., Tan, R., Hoh, C.C., Yee, W.Y., Ngeow, Y.F. and Ng, K.P., 2014. A five-year survey of dematiaceous fungi in a tropical hospital reveals potential opportunistic species. PloS one9(8), p.e104352.

Tan, K.K., Tan, Y.C., Chang, L.Y., Lee, K.W., Nor’e, S.S., Yee, W.Y., Hoh, C.C. and AbuBakar, S., 2017. Geographical distribution of Brucella melitensis inferred from rpoB gene variation. The Journal of Infection in Developing Countries11(05), pp.420-425.

Kuan, C.S., Cham, C.Y., Singh, G., Yew, S.M., Tan, Y.C., Chong, P.S., Toh, Y.F., Atiya, N., Na, S.L., Lee, K.W. and Hoh, C.C., 2016. Genomic Analyses of Cladophialophora bantiana, a Major Cause of Cerebral Phaeohyphomycosis Provides Insight into Its Lifestyle, Virulence and Adaption in Host. PloS one11(8), p.e0161008.

Farhanah, M.I., Yasmin, A.R., Mat Isa, N., Hair-Bejo, M., Ideris, A., Powers, C., Oladapo, O., Nair, V., Khoo, J.S., Ghazali, A.K., Yee, W.Y. and Omar, A.R. 2017. Bursal transcriptome profiling of different inbred chicken lines reveals key differentially expressed genes at 3 days post-infection with very virulent infectious bursal disease virus. Journal of General Virologydoi: 10.1099/jgv.0.000956.

 

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